Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance
نویسندگان
چکیده
منابع مشابه
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance.
Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention in recent years since the discovery that it acts as a potent signaling molecule with wide-ranging effects on many different target tissues. There are currently five identified G protein-coupled receptors for LPA and more are undergoing validation. The complexity of the expression pattern and signaling pr...
متن کاملLysophosphatidic acid (LPA) and its receptors.
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist. Most of these receptors have been genetically deleted in mice toward identifying biological and medically relevant roles. In a...
متن کاملLysophosphatidic acid (LPA) signaling in vertebrate reproduction.
Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA(1-5), and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have identified or implicated important roles for receptor-mediated LPA signaling in multiple aspects...
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Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1-6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female. Studies in various species of animals and also in humans have identified important roles for the receptor-mediated LPA signaling in multiple aspects of human and animal repr...
متن کاملLysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors.
Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA (1 - 100 microg/site) led to increased plasma exudation in the skin. The LPA-...
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ژورنال
عنوان ژورنال: Prostaglandins & Other Lipid Mediators
سال: 2010
ISSN: 1098-8823
DOI: 10.1016/j.prostaglandins.2009.02.002